Bioequivalence and Bioavailability Forum

carry over effect investigation based on what? [General Statistics]

posted by dshah – India, 2023-10-06 15:20 (971 d 16:15 ago) – Posting: # 23746
Views: 12,450

Hi Helmut & Mittyri!

❝ I agree with what Mittyri wrote above. Is is possible that you mixed it up with the 20% of subjects with extrapolated AUC >20%?

Yes, Probability I may have mixed up the things.
But with carry over effect, there is high probability that the subject would not have ratio of AUCt/AUCinf>0.8? which can be due to insufficient washout period? So there is high chance that where carry over is observed, the AUCt/AUCinf> 0.8 is not achieved and thus the investigation on this.

Complete thread:

Carry over and statistical adjustment in BE computations Achievwin 2023-10-02 20:34
- Carry-over → 🚮 Helmut 2023-10-02 21:06
  - Carry-over → 🚮 Achievwin 2023-10-03 12:13
    - Carry-over → 🚮 Helmut 2023-10-03 12:48
    - Carry-over dshah 2023-10-03 16:34
      - Carry-over Achievwin 2023-10-03 20:33
        
        Carry-over Helmut 2023-10-04 08:31
        
        Carry-over Achievwin 2023-10-04 16:38
        
        Carry-over dshah 2023-10-04 11:22
      - more than 20% subject carry over effect investigation mittyri 2023-10-05 20:15
      - carry over effect investigation based on what? Helmut 2023-10-06 07:08
        
        carry over effect investigation based on what?dshah 2023-10-06 13:20
    - Carry-over → 🚮 Mahmoud 2025-12-09 10:47
      - Carry-over → 🚮 Helmut 2025-12-10 10:38
        
        Carry-over → 🚮 Mahmoud 2025-12-11 05:11
- Outdated and wrong answers mittyri 2023-10-05 20:34
  - Wrong answer Helmut 2023-10-06 07:19

carry over effect investigation based on what? [General Sta­tis­tics]

Complete thread:

carry over effect investigation based on what? [General Statistics]