average bioequivalence: MLE vs. REML [General Sta­tis­tics]

posted by Mahmoud  – Jordan, 2023-03-15 09:35 (800 d 10:31 ago) – Posting: # 23503
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❝ ❝ MLE method better when number of fixed effects ≤ 4.

❝ ❝ REML method better when number of fixed effects > 4.

❝

❝ Hi! Always use REML. Use ML only if you know exactly why.


The greater the number of fixed effects, the greater the difference between REML and ML.

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Pharmacokinetics may be simply defined as
what the body does to the drug,
as opposed to pharmacodynamics, which may be defined as
what the drug does to the body.    Leslie Z. Benet

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