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Dear HS,
eventually I missed your point.
My practical experience regarding interaction studies is zero or below.
But if I had understood your suggestion above in the thread, and the chapter in Hauschke et. al., it is enough in a first step of analysis to show that the AUC ratio is with the commonly applied acceptance range. Whatever the correct wording for this result may be.
This was the case in Frieda's study.
Just to cite her initial post:
"The ratio T to R for AUCtau on the last dosing day (n=21) was 0.89, 90% CI 0.85 to 0.94; similar values were obtained for Cmax."
Why to seek for an explanation that this result is wrong?
This seems illogical to me futher on.
(regardless of fiddling with the German purity law forbeer, oh no, no, of course for statistics 
)
eventually I missed your point.
My practical experience regarding interaction studies is zero or below.
But if I had understood your suggestion above in the thread, and the chapter in Hauschke et. al., it is enough in a first step of analysis to show that the AUC ratio is with the commonly applied acceptance range. Whatever the correct wording for this result may be.
This was the case in Frieda's study.
Just to cite her initial post:
"The ratio T to R for AUCtau on the last dosing day (n=21) was 0.89, 90% CI 0.85 to 0.94; similar values were obtained for Cmax."
Why to seek for an explanation that this result is wrong?
This seems illogical to me futher on.
(regardless of fiddling with the German purity law for
)—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- How to deal with a sequence effect? Frieda 2008-08-01 14:36
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- How to deal with a sequence effect? ElMaestro 2008-08-01 16:36
- How to deal with a sequence effect? Frieda 2008-08-06 09:57
- PK interaction studies Helmut 2008-08-01 18:58
- PK interaction studies Frieda 2008-08-06 18:35
- How to deal with a sequence effect? d_labes 2008-08-04 09:23
- How to deal with a sequence effect? Frieda 2008-08-06 13:49
- How to deal with a sequence effect? Helmut 2008-08-10 14:25
- How to deal with a sequence effect?d_labes 2008-08-11 14:50
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- actio est reactio d_labes 2008-08-12 09:55
- actio est reactio Helmut 2008-08-12 12:36
- actio est reactio d_labes 2008-08-12 09:55
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- How to deal with a sequence effect?d_labes 2008-08-11 14:50
- How to deal with a sequence effect? ElMaestro 2008-08-01 16:36
Ing. Helmut Schütz