Bioequivalence and Bioavailability Forum

Dear Helmut,

Thanks for your thoughts and the references! Sorry to be responding this late, was a bit sick for a couple of days.

When we designed the study we did realise that there was more than just the absorbtion part, but since we compared AUCtau at SS all possible kinetic interactions (absorption, distribution and elimination) are in there, I think anyway.

We did sample extensively (4-5 terminal half-lives) at the end of each period (just in case, and to demonstrate that thalf was not affected..) and I do have thalf data. So I will do as you advise, if only to satisfy my own curiosity. In the meantime I know through another 'helper' that there is a period and a sequence effect (p<0.05) despite the randomisation. Will check the subject of period effects on the forum to see if I can work that one out all by myself !

Best wishes,
Frieda