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Hi EM
Thanks for you response!
Meanwhile I have run the ANOVA again with group in it, and this did not make a whole lot of difference, but thanks for the suggestion anyway. One other helper has looked at the data, and there is both a sequence and a period effect (p<0.05), but although statistically significant, not clinically relevant because the study still passes.
You hypothesis is not crackheaded, it is not impossible that something has happened, although by having this long washout, we thought to have avoided that. I guess I wil never know. But there has been sufficient reassurance that the study will pass as is, and suggestions how to word it the report have helped as well!
Frieda
Thanks for you response!
Meanwhile I have run the ANOVA again with group in it, and this did not make a whole lot of difference, but thanks for the suggestion anyway. One other helper has looked at the data, and there is both a sequence and a period effect (p<0.05), but although statistically significant, not clinically relevant because the study still passes.
You hypothesis is not crackheaded, it is not impossible that something has happened, although by having this long washout, we thought to have avoided that. I guess I wil never know. But there has been sufficient reassurance that the study will pass as is, and suggestions how to word it the report have helped as well!
Frieda
Complete thread:
- How to deal with a sequence effect? Frieda 2008-08-01 14:36
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- How to deal with a sequence effect? ElMaestro 2008-08-01 16:36
- How to deal with a sequence effect?Frieda 2008-08-06 09:57
- PK interaction studies Helmut 2008-08-01 18:58
- PK interaction studies Frieda 2008-08-06 18:35
- How to deal with a sequence effect? d_labes 2008-08-04 09:23
- How to deal with a sequence effect? Frieda 2008-08-06 13:49
- How to deal with a sequence effect? Helmut 2008-08-10 14:25
- How to deal with a sequence effect? d_labes 2008-08-11 14:50
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- actio est reactio d_labes 2008-08-12 09:55
- actio est reactio Helmut 2008-08-12 12:36
- actio est reactio d_labes 2008-08-12 09:55
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- How to deal with a sequence effect? d_labes 2008-08-11 14:50
- How to deal with a sequence effect? ElMaestro 2008-08-01 16:36
Ing. Helmut Schütz