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Hi,
there's a lot to think of here.
Perhaps I got somethin wrong, but I think you have another factor possible in your anova: Time of Recruitment with levels "early" (n=7) or "late" (n=14).
Did you try and run an anova with this extra factor? Does it make sense? What were the results like?
Far-fetched and utterly crackheaded hypothesis: B has a long-term effect that causes a decrease in intestinal motility (or a decrease in metabolising enzyme activity or whatever); nothing is seen in Seq RT. But in TR the transit time (or elim. rate or whatever) for the tablet is longer (decreased) in P2 becuase of the effect from B in period 1. Therefore AUC gets higher for R in this seq. Madness? Is B known to induce any enzymes?
EM.
there's a lot to think of here.
Perhaps I got somethin wrong, but I think you have another factor possible in your anova: Time of Recruitment with levels "early" (n=7) or "late" (n=14).
Did you try and run an anova with this extra factor? Does it make sense? What were the results like?
Far-fetched and utterly crackheaded hypothesis: B has a long-term effect that causes a decrease in intestinal motility (or a decrease in metabolising enzyme activity or whatever); nothing is seen in Seq RT. But in TR the transit time (or elim. rate or whatever) for the tablet is longer (decreased) in P2 becuase of the effect from B in period 1. Therefore AUC gets higher for R in this seq. Madness? Is B known to induce any enzymes?
EM.
Complete thread:
- How to deal with a sequence effect? Frieda 2008-08-01 14:36
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- How to deal with a sequence effect?ElMaestro 2008-08-01 16:36
- How to deal with a sequence effect? Frieda 2008-08-06 09:57
- PK interaction studies Helmut 2008-08-01 18:58
- PK interaction studies Frieda 2008-08-06 18:35
- How to deal with a sequence effect? d_labes 2008-08-04 09:23
- How to deal with a sequence effect? Frieda 2008-08-06 13:49
- How to deal with a sequence effect? Helmut 2008-08-10 14:25
- How to deal with a sequence effect? d_labes 2008-08-11 14:50
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- actio est reactio d_labes 2008-08-12 09:55
- actio est reactio Helmut 2008-08-12 12:36
- actio est reactio d_labes 2008-08-12 09:55
- How to deal with a sequence effect? Helmut 2008-08-11 16:33
- How to deal with a sequence effect? d_labes 2008-08-11 14:50
- How to deal with a sequence effect?ElMaestro 2008-08-01 16:36
Ing. Helmut Schütz