Bioequivalence and Bioavailability Forum

Period and sequence effects [General Statistics]

posted by Jaime_R – Barcelona, 2008-08-01 14:55 (6538 d 12:30 ago) – Posting: # 2129
Views: 11,793

Dear Neehtu!

❝ The design used is a 2x2 cross over design.

❝ [...] P-value of period for the test drug for AUCt is 0.0492 [...]

❝ for the refernce drug for AUCt is 0.1577.

I'm as confused as ElMastro. In a 2x2 cross-over it's simply not possible to distinguish between treatment-/period-/sequence-effects separated for treatment (there's just one period effect in ANOVA; not 'PE for test' and 'PE for reference'). Where do you get this numbers from?
Can you please come up with a table here (columns: subject, period, sequence, AUC_t - one row per subject), or provide a link to a text-file for download.
If you decide posting it here, please don't use tabulators to separate columns (see here how to format tables).

—
Regards, Jaime

Complete thread:

Period and sequence effects neethu 2008-07-31 11:44
- Period and sequence effects ElMaestro 2008-07-31 12:15
  - Period and sequence effects neethu 2008-07-31 13:12
    - Period and sequence effects ElMaestro 2008-07-31 13:58
      - Period and sequence effects neethu 2008-08-01 06:16
        
        Period and sequence effects ElMaestro 2008-08-01 08:45
        
        Period and sequence effects neethu 2008-08-01 12:04
        
        Period and sequence effectsJaime_R 2008-08-01 12:55
    - Period and sequence effects shankar 2008-07-31 14:01
      - Period and sequence effects neethu 2008-08-01 12:07
        
        Period and sequence effects ElMaestro 2008-08-01 13:21

Period and sequence effects [General Sta­tis­tics]

Complete thread:

Period and sequence effects [General Statistics]