Bioequivalence and Bioavailability Forum

Period and sequence effects [General Statistics]

posted by ElMaestro – Denmark, 2008-07-31 14:15 (6529 d 12:39 ago) – Posting: # 2117
Views: 11,868

Dear Neethu,

a period effect could arise when the washout period was too short. In that case you might see positive (non-zero) pre-dose levels period 2.
Subject effect is a little different. Generally, not two people on this planet are identical (neither in looks, nor in PK, nor in ...) etc. But we need to bear in mind that the subj effect is evaluted by F being the between-MS divided by within-MS. When F is significant (large) then the between-MS is larger than the within-MS. This gives you joy and happiness in your evaluation of the 90% Conf. interval.

EM.

Complete thread:

Period and sequence effects neethu 2008-07-31 11:44
- Period and sequence effectsElMaestro 2008-07-31 12:15
  - Period and sequence effects neethu 2008-07-31 13:12
    - Period and sequence effects ElMaestro 2008-07-31 13:58
      - Period and sequence effects neethu 2008-08-01 06:16
        
        Period and sequence effects ElMaestro 2008-08-01 08:45
        
        Period and sequence effects neethu 2008-08-01 12:04
        
        Period and sequence effects Jaime_R 2008-08-01 12:55
    - Period and sequence effects shankar 2008-07-31 14:01
      - Period and sequence effects neethu 2008-08-01 12:07
        
        Period and sequence effects ElMaestro 2008-08-01 13:21

Period and sequence effects [General Sta­tis­tics]

Complete thread:

Period and sequence effects [General Statistics]