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Hi DavidManteigas and d_labes,
I beg to differ; the 90% CI approach applies a 5% alpha. A product which in not truly BE (GMR is 0.8 or below; or 1.25 or higher, can't be both), will have at most 5% chance of passing BE; te CI is made from 1.0-2alpha but that does not mean 10% chance of approving a non-BE product.
It is the same alpha 5% that is used in the ANOVA where the null hypo is sameness.
If I am wrong here then it is my very basic understanding of statistics that needs thorough remodeling.
❝ I'm also struggling with the question now. A 90% CI compares with a hypothesis test at 10%. The 90% CI is equivalent to a statistical assessment of equivalente at the 5% level due the TOST approach, since you're not assessing significance for the null hypothesis of difference in means.
I beg to differ; the 90% CI approach applies a 5% alpha. A product which in not truly BE (GMR is 0.8 or below; or 1.25 or higher, can't be both), will have at most 5% chance of passing BE; te CI is made from 1.0-2alpha but that does not mean 10% chance of approving a non-BE product.
It is the same alpha 5% that is used in the ANOVA where the null hypo is sameness.
If I am wrong here then it is my very basic understanding of statistics that needs thorough remodeling.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Relationship between calculated 90% CI and sign. treatment effect in BE GM 2017-03-27 19:40
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 1–2α CI and TOST at α 0.05 Helmut 2017-03-27 23:47
- 1–2α CI and TOST at α 0.05 GM 2017-03-28 06:50
- 1–2α CI and TOST at α 0.05 DavidManteigas 2017-03-28 11:48
- 1–2α CI and TOST at α 0.05 ElMaestro 2017-03-28 13:12
- alpha TOST is not alpha 2-sided d_labes 2017-03-28 15:12
- Interesting! ElMaestro 2017-03-28 21:10
- Google has the answer d_labes 2017-03-29 08:20
- Interesting! DavidManteigas 2017-03-29 11:16
- Interesting!ElMaestro 2017-03-29 11:20
- Interesting! DavidManteigas 2017-03-29 12:28
- 95% CI for a test on difference d_labes 2017-03-29 14:24
- Interesting! GM 2017-03-29 20:06
- Interesting! nobody 2017-03-30 08:24
- Interesting! DavidManteigas 2017-03-29 12:28
- Interesting!ElMaestro 2017-03-29 11:20
- Interesting! ElMaestro 2017-03-28 21:10
- alpha TOST is not alpha 2-sided d_labes 2017-03-28 15:12
- Relationship between calculated 90% CI and sign. treatment effect in BE GM 2017-03-29 12:11
- Relationship between calculated 90% CI and sign. treatment effect in BE DavidManteigas 2017-03-29 12:30
- 1–2α CI and TOST at α 0.05 ElMaestro 2017-03-28 13:12
- 1–2α CI and TOST at α 0.05 DavidManteigas 2017-03-28 11:48
- 1–2α CI and TOST at α 0.05 GM 2017-03-28 06:50
- 1–2α CI and TOST at α 0.05 Helmut 2017-03-27 23:47
Ing. Helmut Schütz