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RegisterAcceptance range for Cmax [General Statistics]
Dear Yura
the width of the confidence interval depends on the variability of the drug and the number of subjects. I guess what you mean is widening of the acceptance range. As explained by ElMaestro this is not possible in case of non highly variable drugs. If you have a non highly variable drug you need to increase the number of subjects in order to tighten the confidence interval in such a way that it fits in the general acceptance range of 80 - 125%.
the width of the confidence interval depends on the variability of the drug and the number of subjects. I guess what you mean is widening of the acceptance range. As explained by ElMaestro this is not possible in case of non highly variable drugs. If you have a non highly variable drug you need to increase the number of subjects in order to tighten the confidence interval in such a way that it fits in the general acceptance range of 80 - 125%.
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Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
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