Bioequivalence and Bioavailability Forum

Hi Silva,

❝ In a crossover study using only one sequence (RT for ex.) does it make sense to include a sequence effect in the ANOVA? And what about the subject nested within sequence?

There is no sequence effect here because Sequence only has one level.
Period and Treatment will have the same meaning; if you include one then addition of the other does not make sense. Looks like a normal linear model with subject and treatment as factors.

But are you sure this is a design you really want to use???

On the positive side regulators will probably not flag you for inspection on grounds of worry about distribution of the randomisation code