comparative bio­avail­ability [General Sta­tis­tics]

posted by hirenpharm – Ahmedabad, 2016-04-15 21:41 (3718 d 13:42 ago) – Posting: # 16207
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Hi Helmut,

Can you please suggest when to use TOST (two one sided t-tests) for comparative bio availability in stead of a standard ANOVA approach using period, treatment, subjects as random effects? I was reading through
https://sphhp.buffalo.edu/content/dam/sphhp/biostatistics/Documents/techreports/UB-Biostatistics-TR1107.pdf
And also-
two one-sided tests” (TOST) proposed by Schuirmann (1987)

http://www.ncss.com/wp-content/themes/ncss/pdf/Procedures/PASS/Equivalence_Tests_for_Two_Means_using_Differences.pdf
—
Dr. Hiren Mehta

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