Bioequivalence and Bioavailability Forum

S×F variance: Followup [General Statistics]

posted by jag009 – NJ, 2015-02-06 18:13 (4153 d 10:14 ago) – Posting: # 14383
Views: 43,980

Hi Angus,

Something is wrong with your computation of H1

We agreed on M_I=0.165897781, dfd=67, X²_p=0.05,67=49.16227018

From your previous post:

❝ Note: my value for H1 (M_I) is 0.11305 and uses CHi value of 49.16227018; it is smaller than your value since CHI (p=0.05) IS 49.16227018

From FDA's equation: H₁=(n-s)*M_I /X²_alpha,n-s

How did you end up with H1=0.11305? I reversed the equation using your H1 value to solve for (n-s) and ended up with (n-s)=33.5.

Looks like your H1 equation is wrong (you used the H2 and H3 equations). FDA's H2 and H3 equations are the same except H2 uses M_T and H3 uses M_R

H= -0.5*(n-s)*M_# / X₂_alpha,n-s, where # = T or R

If you use the correct H1 equation then H1=0.226091092, and the final HQ²D equals to my value of 0.073583

Complete thread:

S×F variance Helmut 2014-12-23 15:32
- S×F variance AngusMcLean 2014-12-23 16:32
  - S×F variance Helmut 2014-12-23 17:17
    - S×F variance AngusMcLean 2014-12-28 23:12
- S×F variance AngusMcLean 2014-12-23 20:56
- S×F variance jag009 2014-12-23 23:07
  - S×F variance AngusMcLean 2014-12-24 01:39
    - S×F variance jag009 2014-12-24 16:21
      - S×F variance AngusMcLean 2014-12-24 17:50
  - S×F variance AngusMcLean 2015-01-06 17:30
    - S×F variance: Followup jag009 2015-01-08 22:42
      - S×F variance: Followup AngusMcLean 2015-01-09 01:44
        
        S×F variance: Followup jag009 2015-01-12 16:53
        
        S×F variance: Followup AngusMcLean 2015-01-12 20:56
        
        S×F variance: 3rd opinion Helmut 2015-01-13 01:25
        
        S×F variance: 3rd opinion AngusMcLean 2015-01-13 20:13
        S×F variance: 3rd opinion AngusMcLean 2015-01-14 21:29
        
        S×F variance: 3rd opinion jag009 2015-01-14 23:00
        
        α vs. 1–α Helmut 2015-01-15 00:54
        
        α vs. 1–α jag009 2015-01-15 22:38
        
        α vs. 1–α Helmut 2015-01-16 00:13
        
        α vs. 1–α jag009 2015-01-19 20:09
        
        α vs. 1–α jag009 2015-01-19 16:02
        
        S×F variance: 3rd opinion AngusMcLean 2015-01-29 23:38
        
        S×F variance: Followup AngusMcLean 2015-01-30 23:24
        
        S×F variance: Followup jag009 2015-02-02 16:31
        
        S×F variance: Followup AngusMcLean 2015-02-02 17:22
        
        S×F variance: Followup jag009 2015-02-05 18:14
        
        S×F variance: Followup AngusMcLean 2015-02-06 01:39
        
        S×F variance: Followupjag009 2015-02-06 17:13
        
        S×F variance: Followup AngusMcLean 2015-02-06 19:36
        
        S×F variance: Followup jag009 2015-02-17 22:49
        
        S×F variance: Followup AngusMcLean 2015-02-19 23:25
        
        S×F variance: Followup jag009 2015-02-21 21:08
        
        S×F variance: Followup AngusMcLean 2015-02-22 17:25
        
        S×F variance: Followup jag009 2015-02-23 16:58
- S×F variance AngusMcLean 2015-01-06 18:48
  - S×F variance jag009 2015-01-07 21:28
    - S×F variance Helmut 2015-01-08 16:10
      - S×F variance: Typo. jag009 2015-01-08 17:32
        
        S×F variance AngusMcLean 2015-01-08 18:51
        
        S×F variance jag009 2015-01-08 20:02
        
        S×F variance AngusMcLean 2015-01-08 20:27
        
        S×F variance jag009 2015-01-08 20:33

S×F vari­­ance: Followup [General Sta­tis­tics]

Complete thread:

S×F variance: Followup [General Statistics]