Bioequivalence and Bioavailability Forum

Calculation of intra-subject CVs in replicate design [General Statistics]

posted by Dr Andrew Leary – Ireland, 2007-12-05 17:35 (6772 d 16:58 ago) – Posting: # 1356
Views: 20,763

Hello Helmut

Any word on the query (in red) below?

Kind regards

Andrew Leary

❝ My question is how to calculate intrasubject CV's for a 4-period 2-treatment replicate bioequivalence trial which I intend to analyze using proc mixed (SAS). I have analysed crossover bioequivalence trials before and used the formula 100%(e^MSE-1)^0.5 to calculate itrasubject CV where MSE is the mean square error. MSE was claculated using proc glm. How should I calculate MSE this time? Do I calculate two separate ANOVA models for each treatment and use the different MSE's from each analysis to give separate intra-subject CV's or do I take a completly different approach?

Complete thread:

Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-11-20 14:50
- Calculation of intra-subject CVs in replicate design Helmut 2007-11-20 16:27
  - Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-11-20 16:46
- Calculation of intra-subject CVs in replicate designDr Andrew Leary 2007-12-05 16:35
  - Calculation of intra-subject CVs in replicate design ddubins 2008-03-01 19:28
    - Data set? Helmut 2008-03-02 13:01
    - Calculation of intra-subject CVs in replicate design d_labes 2008-03-03 12:05
      - Calculation of intra-subject CVs in replicate design Sathya 2008-09-20 08:17
        
        G matrix in SAS Proc Mixed d_labes 2008-09-22 11:35
        
        Wordplay :-) Helmut 2008-09-22 11:47
        G matrix in SAS Proc Mixed Sathya 2008-09-24 11:02
        
        G matrix in SAS Proc Mixed d_labes 2008-09-24 12:46
        
        G matrix in SAS Proc Mixed Sathya 2008-09-25 06:02

Calculation of intra-subject CVs in replicate design [General Sta­tis­tics]

Complete thread:

Calculation of intra-subject CVs in replicate design [General Statistics]