Bioequivalence and Bioavailability Forum

Hello to All,

I need to validate SAS code of steady state study for that I have taken data from Canada guideline part B (1996) from table 12G and 12H. Below table represents the outcome of mine SAS code.
Which is not matching with Canadian guideline result .

Source                  DF      Type I SS       Mean Square     F Value Pr > F
Sequence                1       0.01325957      0.01325957      0.38    0.5414
Subject(Sequence)       10      1.22058634      0.12205863      3.53    0.0055
Period                  1       0.01824931      0.01824931      0.53    0.4744
Form                    1       0.2206856       0.2206856       6.39    0.0185
Subjec*Form(Sequenc)    10      0.56173147      0.05617315      1.63    0.1589
Time                    1       0.03394077      0.03394077      0.98    0.3315
Time*Sequence           1       0.11775951      0.11775951      3.41    0.0772
Time*Subjec(Sequenc)    10      0.33034103      0.0330341       0.96    0.5037
Time*Period             1       0.06284471      0.06284471      1.82    0.19
Time*Form               1       0.02738506      0.02738506      0.79    0.3822
Time*Subj*Form(Sequ)    10      0.29432572      0.02943257      0.85    0.5869


Source          DF      Sum of Squares  Mean Square     F Value Pr > F
Model           47      2.90110908      0.06172573      1.79    0.0634
Error           24      0.82927742      0.03455323
Corrected Total 71      3.7303865

The SAS code is as follows:

Proc glm data= lnconc;
Class Subject seq trtmnt period;
Model pkvalue = Seq subject(seq) period trtmnt subject*trtmnt(seq) time time*seq time*subject(seq) time*period time*trtmnt time*trtmnt*subject(seq)/ss1;
test h= time e= time*subject(seq)/ htype=1 etype=1;;
test h= time*trtmnt e= time*trtmnt*subject(seq)/ htype=1 etype=1;
Run;
quit;

Kindly suggest me where I’m doing a mistake.

Pls suggest how to upload excel file.

Thanks and Regards,

Suchit

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Edit: Uploading Excel-files is not (and will never be) possible. Please see the Forum’s FAQ #11. [Helmut]