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RegisterCalculation of intra-subject CVs in replicate design [General Statistics]
Dear Helmut
I hope that Berlin went well. I contacted you directly earlier this year with a question about the replicate design. You will be glad to see that this time I've used the Forum as requested!
My statistician has the following question:
My question is how to calculate intrasubject CV's for a 4-period 2-treatment replicate bioequivalence trial which I intend to analyze using proc mixed (SAS). I have analysed crossover bioequivalence trials before and used the formula 100%(e^MSE-1)^0.5 to calculate itrasubject CV where MSE is the mean square error. MSE was claculated using proc glm. How should I calculate MSE this time? Do I calculate two separate ANOVA models for each treatment and use the different MSE's from each analysis to give separate intra-subject CV's or do I take a completly different approach?
I hope that you can help.
Kind regards
Dr Andrew Leary
[Shandon Clinic, Cork, IRELAND]
I hope that Berlin went well. I contacted you directly earlier this year with a question about the replicate design. You will be glad to see that this time I've used the Forum as requested!
My statistician has the following question:
My question is how to calculate intrasubject CV's for a 4-period 2-treatment replicate bioequivalence trial which I intend to analyze using proc mixed (SAS). I have analysed crossover bioequivalence trials before and used the formula 100%(e^MSE-1)^0.5 to calculate itrasubject CV where MSE is the mean square error. MSE was claculated using proc glm. How should I calculate MSE this time? Do I calculate two separate ANOVA models for each treatment and use the different MSE's from each analysis to give separate intra-subject CV's or do I take a completly different approach?
I hope that you can help.
Kind regards
Dr Andrew Leary
[Shandon Clinic, Cork, IRELAND]
Complete thread:
- Calculation of intra-subject CVs in replicate designDr Andrew Leary 2007-11-20 14:50
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Calculation of intra-subject CVs in replicate design Helmut 2007-11-20 16:27
- Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-11-20 16:46
- Calculation of intra-subject CVs in replicate design Dr Andrew Leary 2007-12-05 16:35
- Calculation of intra-subject CVs in replicate design ddubins 2008-03-01 19:28
- Data set? Helmut 2008-03-02 13:01
- Calculation of intra-subject CVs in replicate design d_labes 2008-03-03 12:05
- Calculation of intra-subject CVs in replicate design Sathya 2008-09-20 08:17
- G matrix in SAS Proc Mixed d_labes 2008-09-22 11:35
- Wordplay :-) Helmut 2008-09-22 11:47
- G matrix in SAS Proc Mixed Sathya 2008-09-24 11:02
- G matrix in SAS Proc Mixed d_labes 2008-09-24 12:46
- G matrix in SAS Proc Mixed Sathya 2008-09-25 06:02
- G matrix in SAS Proc Mixed d_labes 2008-09-24 12:46
- G matrix in SAS Proc Mixed d_labes 2008-09-22 11:35
- Calculation of intra-subject CVs in replicate design Sathya 2008-09-20 08:17
- Calculation of intra-subject CVs in replicate design ddubins 2008-03-01 19:28
- Calculation of intra-subject CVs in replicate design Helmut 2007-11-20 16:27
Ing. Helmut Schütz