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RegisterEstimate of Intrasubject CV from a study with TX effect [General Statistics]
All,
My knowledge to obtain an accurate intrasubject CV% is to conduct a replicated crossover design dosing same formulation twice.
From a 2x2 crossover study where signiciant treatment effects exist, eg. a significant food-effect study, we are still able to obtain the intrasub CV% from the output.
As I was going to use these intrasub CV% to help biostats to est sample size for a BE study, someone challenged that these number are not real and are likely inflated due to the signficant treatment effect. Is it true? I am wondering does it invalidate the use of intrasub CV% in studies with significant tx effect or these estimates are still close to those from a replicated study.
Many thanks and best regards
zan
Edit: Category changed. [Helmut]
My knowledge to obtain an accurate intrasubject CV% is to conduct a replicated crossover design dosing same formulation twice.
From a 2x2 crossover study where signiciant treatment effects exist, eg. a significant food-effect study, we are still able to obtain the intrasub CV% from the output.
As I was going to use these intrasub CV% to help biostats to est sample size for a BE study, someone challenged that these number are not real and are likely inflated due to the signficant treatment effect. Is it true? I am wondering does it invalidate the use of intrasub CV% in studies with significant tx effect or these estimates are still close to those from a replicated study.
Many thanks and best regards
zan
Edit: Category changed. [Helmut]
Complete thread:
- Estimate of Intrasubject CV from a study with TX effectzan 2014-01-30 00:08
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Variance independent from mean Helmut 2014-01-30 02:12
- Variance independent from mean zan 2014-01-30 18:26
- Estimate of Intrasubject CV from a study with TX effect ElMaestro 2014-01-30 08:38
- Variance independent from mean Helmut 2014-01-30 02:12
Ing. Helmut Schütz