Bioequivalence and Bioavailability Forum

Keeping subjects in mixed-effects models [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2014-01-24 05:18 (4531 d 11:21 ago) – Posting: # 12253
Views: 8,589

Hi Angus,

short answer: Perform the analysis exactly as you have specified it in the protocol.

OK, more serious now. I guess the reference treatment was in fasted state. If R was in period 3, bad luck – no test-ratios. For the FDA the standard setup is a mixed-effects model (also the default in PHX). Try to remove the subject – you should get the same results as if keeping him/her.
If you administered in period 3 one of the tests, keep him/her. You’ll loose one degree of freedom in the respective pairwise comparison (say T₁/R), but still have the full set for the other (T₂/R). Nothing to worry about.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

• BE and drop out subjects Phoenix AngusMcLean 2014-01-24 00:02 
  • Keeping subjects in mixed-effects modelsHelmut 2014-01-24 04:18
    • Keeping subjects in mixed-effects models AngusMcLean 2014-01-24 14:26
      • Keeping subjects in mixed-effects models Helmut 2014-01-24 15:28
        • Keeping subjects in mixed-effects models AngusMcLean 2014-01-24 16:28
          • Keeping subjects in mixed-effects models Helmut 2014-01-24 16:59
        • Keeping subjects in mixed-effects models AngusMcLean 2014-01-26 15:58
          • SAP Helmut 2014-01-26 16:25