Bioequivalence and Bioavailability Forum

Nonlinear nightmare [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2013-11-25 03:56 (4593 d 09:58 ago) – Posting: # 11955
Views: 17,216

Hi John!

❝ I once attempted to simulate carbamazepine (autoinduction) to steady state. Fun stuff...

One of László’s favorites.
Last June after his recent paper* I played around with different types of induction. That’s a 400 mg single dose (Vd 83.5 L, F 1, k_a 0.472 h^-1 (R), 0.94 h^-1 (T1), 3.6 h^-1 (T2), non-induced clearance 1.35 L/h, fully induced 5.84 L/h):

Nice shapes. Steady state was demanding and I put it on the to-do list…

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• Tóthfálusi L, Endrényi L. Approvable generic carbamazepine formulations may not be bioequivalent in target patient populations. Int J Clin Pharmacol Ther. 2013;51(6): 525–8. doi 10.5414/CP201845.

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Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

• Simulation of data to predict Steady state cakhatri 2013-11-24 10:13 
  • Nonparametric superposition Helmut 2013-11-24 14:30
    • Nonparametric superposition jag009 2013-11-24 23:13
      • Nonlinear nightmareHelmut 2013-11-25 02:56
        • Nonlinear nightmare jag009 2013-11-25 17:43
          • Nonlinear nightmare Helmut 2013-11-26 14:32
            • Nonlinear nightmare jag009 2013-11-26 16:00
              • OT: Vienna Helmut 2013-11-26 16:27
                • OT: Vienna jag009 2013-11-26 17:29
                  • OT: Vienna Helmut 2013-11-27 13:04
    • Conc at dosing interval jag009 2013-11-25 17:48
      • Conc at dosing interval Helmut 2013-11-26 15:01
        • Conc at dosing interval jag009 2013-11-26 17:31
          • Conc at dosing interval Helmut 2013-11-27 13:10
            • Conc at dosing interval jag009 2013-11-27 20:00
            • Passing SD and Failing MD luvblooms 2013-11-28 09:19
              • Passing SD and Failing MD Helmut 2013-11-29 17:29
                • Passing SD and Failing MD luvblooms 2013-11-29 18:57
                  • Cτ predictive of Cmin Helmut 2013-11-30 17:25