SS, Unbalanced 3X3 crossover Design [General Sta­tis­tics]

posted by im.sagark – India, 2013-06-06 13:45 (4756 d 19:40 ago) – Posting: # 10741
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❝ Assuming you use a normal linear model and not a mixed model where no SS discussion is particularly relevant, in matrix notation you have logPK=y=Xb+e. So if you construct your design matrices X appropriately then you can analytically estimate the maximum likelihood b (max likelihood is here a minimisation of eTe) using for example

❝ b=(XtX)-1Xty


Here I don't have equal number of subjects in each group. So the design is Unbalanced one.
How can I deal with this sort of problem??
And Should I consider carryover effect also??

Regards,
Sagar Khandagale
—
Regards,
Sagar Khandagale.

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