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RegisterTmax, ke and t1/2 in fully replicate design of HVD [General Statistics]
Dear All,
When we run a fully replicate design for highly variable drug, may I know how elimination rate constant (ke) and elimination half-life (t1/2) are analyzed statistically ? Same as for AUC ??
What about Tmax ? As Tmax is analyzed statistically using non-parametric test for 2-way crossover design (2x2), I presumed this parameter should also be analyzed the same way for fully replicate design (2x4). The only difference is taking the average of Tmax of test and reference product.
Appreciate if could kindly comment on the above.
Thank you.
Regards,
Ken
When we run a fully replicate design for highly variable drug, may I know how elimination rate constant (ke) and elimination half-life (t1/2) are analyzed statistically ? Same as for AUC ??
What about Tmax ? As Tmax is analyzed statistically using non-parametric test for 2-way crossover design (2x2), I presumed this parameter should also be analyzed the same way for fully replicate design (2x4). The only difference is taking the average of Tmax of test and reference product.
Appreciate if could kindly comment on the above.
Thank you.
Regards,
Ken
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