Bioequivalence and Bioavailability Forum

MSE of partial replicate design [General Statistics]

posted by d_labes – Berlin, Germany, 2013-04-10 12:28 (4817 d 19:34 ago) – Posting: # 10392
Views: 5,834

Dear ElMaestro,

Thanks for the quick answer.

I simulated with a mixed model, but without subject-by-formulation interaction. Without missings. With balanced sequence groups. I guess that you know for what end :-D

.

I analyzed with simple ANOVA all effects fixed (effects: treatment, period, subject for simplicity since the sequence doesn't change the mse) as the Mighty Oracle demands us to do so :crying:

❝ In a mixed model -if that's you case cf above- you have a V where the diagonal is either

❝ a. s2wT+s2bT or s2wT+s2bT (full repl.)

❝ b. s2wT or s2wR+s2bR (partial repl.)

I have a V matrix (example subject in sequence TRR, i.e. 2x3x3 design)

s2b+s2wT  s2b       s2b

s2b       s2b+s2wR  s2b

s2b       s2b       s2b+s2wR

where s2b is the common between-subject variance.

—
Regards,

Detlew

Complete thread:

MSE of partial replicate design d_labes 2013-04-10 09:30
- MSE of partial replicate design ElMaestro 2013-04-10 09:51
  - MSE of partial replicate designd_labes 2013-04-10 10:28
    - MSE of partial replicate design ElMaestro 2013-04-10 10:38
      - MSE of partial replicate design d_labes 2013-04-10 11:15
        
        MSE of partial replicate design ElMaestro 2013-04-11 00:07

MSE of partial replicate design [General Sta­tis­tics]

Complete thread:

MSE of partial replicate design [General Statistics]