Bioequivalence and Bioavailability Forum

Dear Suchit,

❝ If temperature has been observed up to 90 degree celsius during the shipment/ segregation, is it acceptable, kindly give your suggestion

I suppose you mean - 90°C. Otherwise I think the answer to your question is a clear no

I'm a bit surprised that you measured a temperature of -90°C during shipment and segregation. Dry ice normally sublimates at -78.5°C at atmospheric pressure. I would first check the recommended usage range of the temperature probe used to measure that temperature, its qualification/certification and the uncertainty of measurement at such temperatures.

Regarding the effect of such a deviation, if confirmed, on your samples: I would not be worried unless you are working on a biological product (protein or peptide).

Regards
Ohlbe