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RegisterBE of Effervescent Tablets [Study Performance]
Dear Shyam,
"Dissolution" of an effervescent tablet does not mean dissolution of the active substance it contains, and you may actually get a suspension. If you read the ranitidine guidance further, it continues with "Subsequently, after swallowing the solution, any residue should be re-suspended in 240 mL of water and swallowed by the subjects".
Regards
Ohlbe
❝ Gone through the Guideline for Ranitidine effervescent tablets, its state that ""Wait until the tablet is completely dissolved before administering the solution."". My query is that as we are converting the tablet in solution, is it necessary to study the BE??. 
"Dissolution" of an effervescent tablet does not mean dissolution of the active substance it contains, and you may actually get a suspension. If you read the ranitidine guidance further, it continues with "Subsequently, after swallowing the solution, any residue should be re-suspended in 240 mL of water and swallowed by the subjects".
Regards
Ohlbe
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Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- BE of Effervescent Tablets joyjac 2012-01-12 09:45
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- BE of Effervescent Tablets MGR 2012-01-12 12:14
- Check absorption! Helmut 2012-01-13 17:11
- BE of Effervescent Tablets shyam_5p 2012-01-31 06:55
- BE of Effervescent TabletsOhlbe 2012-01-31 17:55
- BE of Effervescent Tablets shyam_5p 2012-02-01 04:01
- BE of Effervescent Tablets drgunasakaran1 2012-01-31 18:01
- BE of Effervescent Tablets shyam_5p 2012-02-08 11:24
- BE of Effervescent TabletsOhlbe 2012-01-31 17:55
- BE of Effervescent Tablets MGR 2012-01-12 12:14
Ing. Helmut Schütz