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RegisterSimvastatin Cmax [Study Performance]
Dear dr suresh gidwani
you can try it this way
The lower Cmax of simvastatin, the inactive prodrug, is not expected to have any clinical significance particularly when the AUC0-t and AUC0-inf; of simvastatin is bioequivalent to that of the reference tablet. Besides the active metabolite beta hydroxyacid of Simvastatin is complying the 90% confidence for Cmax, AUC(0-t), AUC(0-inf).
And for support you can get a lot of data from mhra website.
hope this will help
Srinetram
you can try it this way
The lower Cmax of simvastatin, the inactive prodrug, is not expected to have any clinical significance particularly when the AUC0-t and AUC0-inf; of simvastatin is bioequivalent to that of the reference tablet. Besides the active metabolite beta hydroxyacid of Simvastatin is complying the 90% confidence for Cmax, AUC(0-t), AUC(0-inf).
And for support you can get a lot of data from mhra website.
hope this will help
Srinetram
Complete thread:
- Simvastatin Cmax dr suresh gidwani 2010-08-10 12:24
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Simvastatin CmaxSrinetram 2010-08-11 14:05
- Simvastatin = prodrug Helmut 2010-08-12 16:35
- Simvastatin = prodrug dr suresh gidwani 2010-08-16 06:28
- Simvastatin = prodrug Helmut 2010-08-12 16:35
- Simvastatin CmaxSrinetram 2010-08-11 14:05
Ing. Helmut Schütz