Log in
RegisterDonepezil SR 23 mg Tablets BE study [Study Performance]
Dear Members,
Thank You very much Dr.Gunasakaran for your reply. I still had a doubt regarding the use of antiemetic for Donepezil as it was clearly reported that it causes severe nausea and vomiting. I would like you suggest a proper Antiemetic in order to avoid emesis and subject withdrawal in the conduct of Bioequivalence study.
Is it approriate to choose Ondansetron (a substrate of CYP 3A4) as an antiemetic in BA/BE study of Donepezil (which is also a substrate of CYP 3A4) in order to avoid emesis? It would be highly appreciated if u share any literature study conducted on donepezil using antiemetic.
Thanking You in ancipation
Awaiting Your Reply.
Regards,
MadhavRaoB
Thank You very much Dr.Gunasakaran for your reply. I still had a doubt regarding the use of antiemetic for Donepezil as it was clearly reported that it causes severe nausea and vomiting. I would like you suggest a proper Antiemetic in order to avoid emesis and subject withdrawal in the conduct of Bioequivalence study.
Is it approriate to choose Ondansetron (a substrate of CYP 3A4) as an antiemetic in BA/BE study of Donepezil (which is also a substrate of CYP 3A4) in order to avoid emesis? It would be highly appreciated if u share any literature study conducted on donepezil using antiemetic.
Thanking You in ancipation
Awaiting Your Reply.
Regards,
MadhavRaoB
Complete thread:
- Donepezil SR 23 mg Tablets BE study madhavaraob 2010-07-07 07:27
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Donepezil SR 23 mg Tablets BE study drgunasakaran1 2010-07-17 07:23
- Donepezil SR 23 mg Tablets BE studymadhavaraob 2010-07-22 09:06
- Donepezil SR 23 mg Tablets BE study Pavidus 2010-07-22 10:09
- Donepezil SR 23 mg Tablets BE study chaitanyag 2010-07-23 05:18
- Donepezil SR 23 mg Tablets BE study Pavidus 2010-07-22 10:09
- Donepezil SR 23 mg Tablets BE study chaitanyag 2010-07-26 14:34
- CROs Helmut 2010-07-26 15:01
- Donepezil SR 23 mg Tablets BE study Dr. Solanki 2010-08-07 10:28
- Donepezil SR 23 mg Tablets BE study Dr. Solanki 2010-08-12 11:30
- Donepezil SR 23 mg Tablets BE studymadhavaraob 2010-07-22 09:06
- Donepezil SR 23 mg Tablets BE study drgunasakaran1 2010-07-17 07:23
Ing. Helmut Schütz