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RegisterPaired design [Study Performance]
posted by Helmut 
– Vienna, Austria, 2008-11-24 15:32 (6014 d 06:41 ago) – Posting: # 2789
Views: 9,613
Dear Shankar!
Yes, this happens from time to time.
Sure. If you want to compare between studies and the same subjects were attending, you may use a paired comparison (only fixed effects: subject+study+subject(study)).
A lower variability than if different subjects would have been used (parallel design). In other words, if you calculate BA between studies your confidence intervals will be tighter - and your point estimates more reliable.
❝ One of our client want to conduct the bioavailability of particular drug
❝ with same volunteer in two different studies.
Yes, this happens from time to time.
❝ I think we may get pharmacokinetic pattern of two different formulations
❝ in same volunteers. I am not sure whether it's right or wrong.
Sure. If you want to compare between studies and the same subjects were attending, you may use a paired comparison (only fixed effects: subject+study+subject(study)).
❝ What else we can achieve this type of studies.
A lower variability than if different subjects would have been used (parallel design). In other words, if you calculate BA between studies your confidence intervals will be tighter - and your point estimates more reliable.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- Same Volunteers In Two Different Studies shankar 2008-11-24 07:10
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Paired designHelmut 2008-11-24 14:32
- Paired design BE 2008-11-25 06:01
- Paired design d_labes 2008-11-25 10:06
- Paired design shankar 2008-11-25 06:50
- Repeated / previous study d_labes 2008-11-25 09:56
- Repeated / previous study shankar 2008-11-25 11:12
- To pool or not to pool d_labes 2008-11-25 11:52
- Not to pool ;-) Helmut 2008-11-25 12:25
- Not to pool ;-) is best pooling d_labes 2008-11-25 13:14
- Not to pool is best billiards ;-) Helmut 2008-11-25 13:20
- Pool is to big d_labes 2008-11-25 13:28
- Not to pool is best billiards ;-) Helmut 2008-11-25 13:20
- Not to pool ;-) is best pooling d_labes 2008-11-25 13:14
- Not to pool ;-) Helmut 2008-11-25 12:25
- Repeated / previous study Ohlbe 2008-11-25 11:54
- Bioavailability Comparison shankar 2008-11-25 12:24
- Bioavailability Comparison Helmut 2008-11-25 12:29
- Bioavailability Comparison shankar 2008-11-25 12:45
- Non Regulatory Submission shankar 2008-11-29 07:06
- Bioavailability Comparison shankar 2008-11-25 12:45
- Bioavailability Comparison Helmut 2008-11-25 12:29
- Bioavailability Comparison shankar 2008-11-25 12:24
- To pool or not to pool d_labes 2008-11-25 11:52
- Repeated / previous study shankar 2008-11-25 11:12
- Repeated / previous study d_labes 2008-11-25 09:56
- Paired design BE 2008-11-25 06:01
- Paired designHelmut 2008-11-24 14:32
Ing. Helmut Schütz