Bioequivalence and Bioavailability Forum

Hi PVRC,

❝ If the AUC0-t is not affected by the missing sample in the elimination phase can the data from such a subject be considered for analysis..?

What does your protocol say? It boils down how long you sampled. See also this article, esp. the section about Missings.

With a half life of 12 hours and the last sample at 8 hours in the first period, a comparison of AUC_0–t will be biased. Essentially you have two options:

1. Compare in this subject AUC_0–8 (see also this post).
   
2. Exclude the subject from the comparison of AUC but keep him/her for the comparison of C_max. Since commonly studies are powered for C_max with its higher variability, the impact on power of AUC is a minor one.