Bioequivalence and Bioavailability Forum

Randomisation? [Study Per­for­mance]

posted by Helmut  – Vienna, Austria, 2014-06-10 16:53 (3988 d 13:55 ago) – Posting: # 13050
Views: 18,137

Hi ElMaestro & Khaoula,

❝ I think what was meant was that the allocated sequence for subject 15 is unknown/missing/evaporated/gone/lost? If aiming for balance which is standard you may be able to guess it pretty well provided the sequences of the other 8+7 subjects are correct

Since we have seven subjects in sequence RT and eight in sequence TR, we might guess that #15 was planned for sequence RT.

❝ Anyways, guessing isn't science,

Yep.

❝ and I just wonder how such an event could happen […]

Khaoula wrote in her OP:

❝ ❝ we have design of bioequivalence study cross over design with 16 subject (randomised), but at the firt period the 15 suject didn't come […]

❝ How could info on randomisation for a single subject be missing?

Good question.

❝ ❝ without protocol for the management of dropouts

I wouldn’t call #15 a “drop-out” but rather a “no-show”.

—
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Helmut Schütz


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Complete thread:

• randomization khaoula 2014-06-06 14:04 
  • Imbalanced cross-overs Helmut 2014-06-06 14:47
    • Imbalanced cross-overs khaoula 2014-06-06 16:03
      • CV 0.03%? Helmut 2014-06-07 13:52
      • Imbalanced cross-overs jag009 2014-06-09 15:36
        • Imbalanced cross-overs khaoula 2014-06-09 22:07
          • Bag full of bugs Helmut 2014-06-10 00:37
            • Randomisation? ElMaestro 2014-06-10 01:00
              • Randomisation?Helmut 2014-06-10 14:53
                • Randomisation? khaoula 2014-06-11 00:17
                  • Problems resolved? Helmut 2014-06-11 02:01
                    • Problems resolved? khaoula 2014-07-24 13:36
                      • corrected data in PHX/WNL Helmut 2014-07-27 01:37
          • Which version of Kinetica? Helmut 2014-06-11 19:51
            • Which version of Kinetica? khaoula 2014-06-12 00:41
            • Which version of Kinetica? khaoula 2014-07-25 00:49
              • adjusted means (aka LSMs) Helmut 2014-07-27 02:23
                • adjusted means (aka LSMs) khaoula 2014-08-25 21:41