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RegisterCV 0.03%? [Study Performance]
posted by Helmut 
– Vienna, Austria, 2014-06-07 15:52 (3991 d 14:32 ago) – Posting: # 13041
Views: 18,695
Hi Khaoula,
Agree.
The 0.03% you stated above are practically impossible. Even if you had only monozygotic multiples in your study (violating the “independence” of IID) there would still be variability of the bioanalytical method as a component of the residual variance. Exceptionally good methods still have a CV of ~2–3%. The lowest CVintra of Cmax I ever have seen was ~7% (more than two orders of magnitude higher than yours). Please check your calculations:
❝ […] the drug is omeprazole, that is a HVDP (in bibliography I read a lot of bioequivalence stydy were CV > 30%)
Agree.
❝ […] CV C max of the study Was very low!!!!!!!!
The 0.03% you stated above are practically impossible. Even if you had only monozygotic multiples in your study (violating the “independence” of IID) there would still be variability of the bioanalytical method as a component of the residual variance. Exceptionally good methods still have a CV of ~2–3%. The lowest CVintra of Cmax I ever have seen was ~7% (more than two orders of magnitude higher than yours). Please check your calculations:
\(CV\% = 100\sqrt{e^{MSE}-1}\), where MSE is obtained from ANOVA/GLM of ln-transformed data.
Avoid Kinetica.—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
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Complete thread:
- randomization khaoula 2014-06-06 14:04
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Imbalanced cross-overs Helmut 2014-06-06 14:47
- Imbalanced cross-overs khaoula 2014-06-06 16:03
- CV 0.03%?Helmut 2014-06-07 13:52
- Imbalanced cross-overs jag009 2014-06-09 15:36
- Imbalanced cross-overs khaoula 2014-06-09 22:07
- Bag full of bugs Helmut 2014-06-10 00:37
- Randomisation? ElMaestro 2014-06-10 01:00
- Randomisation? Helmut 2014-06-10 14:53
- Randomisation? khaoula 2014-06-11 00:17
- Problems resolved? Helmut 2014-06-11 02:01
- Problems resolved? khaoula 2014-07-24 13:36
- corrected data in PHX/WNL Helmut 2014-07-27 01:37
- Problems resolved? khaoula 2014-07-24 13:36
- Problems resolved? Helmut 2014-06-11 02:01
- Randomisation? khaoula 2014-06-11 00:17
- Randomisation? Helmut 2014-06-10 14:53
- Randomisation? ElMaestro 2014-06-10 01:00
- Which version of Kinetica? Helmut 2014-06-11 19:51
- Which version of Kinetica? khaoula 2014-06-12 00:41
- Which version of Kinetica? khaoula 2014-07-25 00:49
- adjusted means (aka LSMs) Helmut 2014-07-27 02:23
- adjusted means (aka LSMs) khaoula 2014-08-25 21:41
- adjusted means (aka LSMs) Helmut 2014-07-27 02:23
- Bag full of bugs Helmut 2014-06-10 00:37
- Imbalanced cross-overs khaoula 2014-06-09 22:07
- Imbalanced cross-overs khaoula 2014-06-06 16:03
- Imbalanced cross-overs Helmut 2014-06-06 14:47
Ing. Helmut Schütz