blood loss < donation (500ml) [Study Per­for­mance]

posted by Helmut Homepage – Vienna, Austria, 2007-11-15 16:53 (6793 d 08:04 ago) – Posting: # 1299
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Dear Vishal,

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❝ … total blood loss is 480ml in 4 Periods with wash out period of one week between periods.

❝ Do you know of any guideline which says that we need to check the Hb (hemoglobin) of the subjects before the start of Period III.


No guideline I know of.
Generally blood loss comparable to a single bood donation (500 mL) in a 2-period study does not rise medical/ethical concerns. IMHO your planned design should not be problematic.

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