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RegisterDifference between compartmental and Noncompartmental [Software]
Hi Hari,
There is no separate definition for differentiating compartmental and non-compartmental models specifically for WinNonlin. You can obtain this knowledge in any standard Pharmacokinetics book. For beginners Handbook in Pharmacokinetics by WA Ritchel is a good ready reference book. WinNonlin also use the same definition and science.
Briefly, Compartmental models do not assume instantaneous distribution of drug throughout the body and you may find two or more segments in the elimination phase when you plot log concentration versus time on a graph paper. Whereas in non-compartmental model you will find a straight line in the elimination phase, this is because the drug is assumed to be instantaneously distributed througout the body and the drug is mostly confined to blood volume. These compartments can be explained using macro or micro rate constants. I think WinNonlin has both the options.
Dr. Shiv
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Edit: Full quote removed. Please see this post! [Jaime]
There is no separate definition for differentiating compartmental and non-compartmental models specifically for WinNonlin. You can obtain this knowledge in any standard Pharmacokinetics book. For beginners Handbook in Pharmacokinetics by WA Ritchel is a good ready reference book. WinNonlin also use the same definition and science.
Briefly, Compartmental models do not assume instantaneous distribution of drug throughout the body and you may find two or more segments in the elimination phase when you plot log concentration versus time on a graph paper. Whereas in non-compartmental model you will find a straight line in the elimination phase, this is because the drug is assumed to be instantaneously distributed througout the body and the drug is mostly confined to blood volume. These compartments can be explained using macro or micro rate constants. I think WinNonlin has both the options.
Dr. Shiv
--
Edit: Full quote removed. Please see this post! [Jaime]
Complete thread:
- Difference between compartmental and Noncompartmental Hari 2007-07-11 09:47
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WinNonlin: PK and NCA Helmut 2007-07-11 13:12
- Difference between compartmental and Noncompartmentaldrshiv 2007-08-15 16:23
- Difference between compartmental and Noncompartmental Helmut 2007-08-15 22:57
- Difference between compartmental and Noncompartmental jag009 2012-03-23 15:59
- Micro ⇒ macro Helmut 2012-03-23 18:24
- for Deconvolution fans mittyri 2024-07-23 15:02
- Micro ⇒ macro Helmut 2012-03-23 18:24
- Difference between compartmental and Noncompartmental jag009 2012-03-23 15:59
- Difference between compartmental and Noncompartmental Helmut 2007-08-15 22:57
Ing. Helmut Schütz