Bioequivalence and Bioavailability Forum

Steady state calculation using WinNonlin [Software]

posted by Helmut  – Vienna, Austria, 2007-08-02 17:07 (6492 d 14:02 ago) – Posting: # 958
Views: 20,296

Dear Imran!

❝ How can we calculate or prove that SS is achieved.

❝ I had used SAS for the same by repeated measures of ANOVA for Cpd calculation, and withdrawn the conclusion based on time* formulation interaction (p value.)

In never understood this procedure. OK, statistically yes, but would you really throw away an entire study based on such a result? I always preferred it to look at the time course of the subjects and eventually exclude only ones who were not in steady state on the profile day. Of course you have to state this procedure in the protocol.

❝ What procedure to be followed by using Winnonlin 5.0.1. or any other suitable method can be used to prove SS is achived.

For my personal suggestions see this tread.

If you want to perform the analogue of SAS' repeated measures ANOVA, you will have to fight yourself through WinNonlin's Linear Mixed Effects Modeling feature - and if you succeed, come back and tell us how you did it!

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Steady state calculation using WinNonlin Imran 2007-06-27 06:02 
  • Steady state calculation using WinNonlin Helmut 2007-06-27 11:56
    • Steady state calculation using WinNonlin Imran 2007-06-29 05:13
      • Please use the Preview! Jaime_R 2007-06-29 10:29
        • Please use the Preview! Imran 2007-06-30 12:50
          • no attachments and uploads... Jaime_R 2007-06-30 13:33
      • Steady state calculation using WinNonlin Helmut 2007-06-29 21:08
        • Steady state calculation using WinNonlin Imran 2007-08-02 13:52
          • Steady state calculation using WinNonlinHelmut 2007-08-02 15:07
            • Steady state calculation using WinNonlin Imran 2007-08-06 11:48
              • Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16
                • Exclusion of subjects who are not in SS KR 2009-04-13 14:34
                • Exclusion of subjects who are not in SS vixen 2020-04-27 10:10
                  • Common sense instead of statistics Helmut 2020-04-27 11:45