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Register6x3 crossover design in Pharsight Winnonlin program [Software]
Hi i'm SW
I have a question about BE calculation in Pharsight Winnonlin
I designed 6x3 crossover BE study to evaluate bioequivalence between tablet(R) and ODF(T). subjects took ODF with(T1) and without(T2)water.
2 subject included in each sequence, so total subject number is 24.
i put AUC and Cmax value of those subjects into winnonlin, and executed BE test. but there is no intra CV% value in result table... (T/R ratio and all kinds of CI interval was calculated)
1. how can i get intra subj CV%?
2. In my case, 6x3 crossover is appropriate design?
3. If I perform winnonlin BE test separately, (first performance is for R and T1, and the next one is for R and T2) is it OK?
Yours Sincerely
I have a question about BE calculation in Pharsight Winnonlin
I designed 6x3 crossover BE study to evaluate bioequivalence between tablet(R) and ODF(T). subjects took ODF with(T1) and without(T2)water.
Sequence period 1 period 2 period 3
A R T1 T2
B R T2 T1
C T T R
D T1 R T2
E T2 R T1
F T2 T1 R2 subject included in each sequence, so total subject number is 24.
i put AUC and Cmax value of those subjects into winnonlin, and executed BE test. but there is no intra CV% value in result table... (T/R ratio and all kinds of CI interval was calculated)
1. how can i get intra subj CV%?
2. In my case, 6x3 crossover is appropriate design?
3. If I perform winnonlin BE test separately, (first performance is for R and T1, and the next one is for R and T2) is it OK?
Yours Sincerely
Complete thread:
- 6x3 crossover design in Pharsight Winnonlin programlovemysoul 2012-10-30 09:19
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CVintra higher-order Xover (PHX/WNL) Helmut 2012-10-30 23:17
- 6x3 crossover design - number of subjects d_labes 2012-10-31 11:36
- 6x3 crossover design - number of subjects lovemysoul 2012-11-07 03:38
Ing. Helmut Schütz