Bioequivalence and Bioavailability Forum • WinNonlin – IVIVC Toolkit

WinNonlin – IVIVC Toolkit [Software]

posted by jag009 – NJ, 2012-10-01 19:41 (4587 d 07:14 ago) – Posting: # 9291
Views: 8,212
(edited on 2012-10-01 22:32)

Hi Sam,

You have in-vivo and in-vitro data from how many formulations? Can't you tell which one is faster than the other? You should have 3+ formulations to do an IVIVC.
Do you have an IR or IV profile to serve as the impulse function?
Are you trying to generate an IVIVC with vivo data and vitro data from each pH? ie: IVIVC for pH 1.0, IVIVC for pH 4.5, IVIVC for pH 6.8?

John

Complete thread:

WinNonlin – IVIVC Toolkit sam 2012-09-28 13:28
- WinNonlin – IVIVC Toolkitjag009 2012-10-01 17:41
  - WinNonlin – IVIVC Toolkit sam 2012-10-03 09:18
    - WinNonlin – IVIVC Toolkit jag009 2012-10-03 16:06
      - Proportionality-based biowaiver ≠ IVIVC Helmut 2012-10-03 16:13
- in vivo first Helmut 2012-10-03 15:46
  - in vivo first sam 2012-10-04 12:08
    - RTFM Helmut 2012-10-04 14:17
    - in vivo first jag009 2012-10-04 16:10
      - in vivo first sam 2012-10-05 07:32
        
        in vivo first jag009 2012-10-05 22:51
        
        in vivo first Helmut 2012-10-06 01:23
        
        in vivo first jag009 2012-10-08 18:13
        
        OT Helmut 2012-10-08 19:19

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