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Dear All,
I wanted to do the IVIVC of few formulations and I have with me the invitro data of the formulation at different pH like 1.2, 6.5 and 7.4. I have also invivo data. I am handling the IVIVC toolkit for doing the IVIVC.
Now plz suggest me which data i have to select as fast relaese and slow release data and secondly which data will be considered as internal validation and external validation data.
I have gone through the examples and manual guidance of the winnonlin. From there I did practice on their provided data. But I am bit confused that which data I have to select for the internal validation and which data for external validation from my invitro data of different pH.
In the example guide it has been written as
Edit: Category and subject line changed. [Helmut]
I wanted to do the IVIVC of few formulations and I have with me the invitro data of the formulation at different pH like 1.2, 6.5 and 7.4. I have also invivo data. I am handling the IVIVC toolkit for doing the IVIVC.
Now plz suggest me which data i have to select as fast relaese and slow release data and secondly which data will be considered as internal validation and external validation data.
I have gone through the examples and manual guidance of the winnonlin. From there I did practice on their provided data. But I am bit confused that which data I have to select for the internal validation and which data for external validation from my invitro data of different pH.
In the example guide it has been written as
- Drag CR01, CR02, and then CR04 from the Formulations list to the Internal Validation field. These formulations will be used to fit the IVIVC.
- Drag CR03 to the External Validation field. It will be used to validate the IVIVC on the Correlation tab.
- Drag Targ to the Target Batch field. It will provide the comparator for predictions made on the Predictions tab.
Edit: Category and subject line changed. [Helmut]
Complete thread:
- WinNonlin – IVIVC Toolkitsam 2012-09-28 13:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WinNonlin – IVIVC Toolkit jag009 2012-10-01 17:41
- WinNonlin – IVIVC Toolkit sam 2012-10-03 09:18
- WinNonlin – IVIVC Toolkit jag009 2012-10-03 16:06
- Proportionality-based biowaiver ≠ IVIVC Helmut 2012-10-03 16:13
- WinNonlin – IVIVC Toolkit jag009 2012-10-03 16:06
- WinNonlin – IVIVC Toolkit sam 2012-10-03 09:18
- in vivo first Helmut 2012-10-03 15:46
- in vivo first sam 2012-10-04 12:08
- RTFM Helmut 2012-10-04 14:17
- in vivo first jag009 2012-10-04 16:10
- in vivo first sam 2012-10-05 07:32
- in vivo first jag009 2012-10-05 22:51
- in vivo first Helmut 2012-10-06 01:23
- in vivo first jag009 2012-10-08 18:13
- OT Helmut 2012-10-08 19:19
- in vivo first jag009 2012-10-08 18:13
- in vivo first Helmut 2012-10-06 01:23
- in vivo first jag009 2012-10-05 22:51
- in vivo first sam 2012-10-05 07:32
- in vivo first sam 2012-10-04 12:08
- WinNonlin – IVIVC Toolkit jag009 2012-10-01 17:41
Ing. Helmut Schütz