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Hi jag009!
Yes, you are right. I need to compare IR tablets 500 mg (2 times/day) and CR tablets 1000 mg (once a day).
No. After steady state 14 days Cmin of IR tabl is 2600 ng/ml, Cmin of CR tabl is 1000 ng/ml. Tmax is 5 hours for both. The time-concentration profile has double peak.
Does it mean that CR tabl has specific absorption sites?
Thank you.
❝ I assume you are comparing AUC IR bid vs AUC CR in males.
Yes, you are right. I need to compare IR tablets 500 mg (2 times/day) and CR tablets 1000 mg (once a day).
❝ 1. Are the trough levels (or concentration at time 0 or time 24) between the IR bid and CR q.d. at steady state similar?
No. After steady state 14 days Cmin of IR tabl is 2600 ng/ml, Cmin of CR tabl is 1000 ng/ml. Tmax is 5 hours for both. The time-concentration profile has double peak.
Does it mean that CR tabl has specific absorption sites?
Thank you.
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