Bioequivalence and Bioavailability Forum

Dear Helmut,

Question about your statment

❝ Micro- and macro-constants are applicable to compartmental models only.

❝ Any multicompartmental model can be formulated as a sum of exponential terms:

❝     \(C_{ij}=\text{A}_j\cdot \text{e}^{\text{B}_j\cdot t_i}\textsf{,}\)

❝ where the index \(\small{i}\) denotes the sampling time point, and the index \(\small{j}\) the number of the exponential term.

❝ The coefficients (\(\small{\text{A}_j}\)) and – in some terminologies only the exponents – (\(\small{\text{B}_j}\)) are called macro-constants.

Can I compute macro constant for a one-compartment model? I used winnonlin to fit my IR profile and the best fit was a one compartment model with lagtime. But in order for me to use the information to deconvolute my prototype formulation's profile in Win­nonlin, I was asked to provide the A and Alpha parameters in the Deconvolution module... I know how to figure out the macro constants from micro constants for a multicompartment model. Winnonlin's 2nd parameter output (from the modelling model) doesn't give out the macro constants for a one compartment model. It does give out the macro and micro constants for a 2 compartment model.

Thank you.

Jag.

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Edit: Original quotes restored. [Helmut]