Bioequivalence and Bioavailability Forum • WinNonlin is lack of precision or?

WinNonlin is lack of precision or? [Software]

posted by Helmut – Vienna, Austria, 2011-11-06 15:46 (5349 d 00:30 ago) – Posting: # 7621
Views: 13,667

Dear yicaoting!

❝ But you as everyone know (as WNL's usr guide pointed, Phoenix WinNonlin 6.0 guide Page 338), to convert

❝ 90% CI of LSMean(R-T) to 90% CI of GeoMean Ratio(%) (T/R), we only need a simple calculation like

❝ CI_Lower = 100 · exp(lower)

❝ CI_Upper = 100 · exp(upper)

❝ No iteration is needed, and no optimization algorithm is needed.

See my other post. No optimization here, but lower and upper are obtained by REML (as ElMaestro pointed out). Default settings in PHX/WNL are maximum 50 iterations, estimability tolerance 10^-5, singularity tolerance 10^-10, convergence criterion 10^-10. BTW, with our dataset convergence is reached in the first iteration [-2×REML log(likelihood) 4.8289659].

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

WinNonlin is lack of precision or? yicaoting 2011-11-06 13:03
- WinNonlin is lack of precision or? ElMaestro 2011-11-06 13:46
  - WinNonlin is lack of precision or? yicaoting 2011-11-06 14:20
    - WinNonlin is lack of precision or? ElMaestro 2011-11-06 14:32
      - WinNonlin is lack of precision or? yicaoting 2011-11-06 14:59
        
        EOD? Helmut 2011-11-06 15:39
    - WinNonlin is lack of precision or?Helmut 2011-11-06 14:46
      - use an ox cleaver to kill a chicken yicaoting 2011-11-06 15:25
        
        use an ox cleaver to kill a chicken Helmut 2011-11-06 15:47
- WinNonlin’s BE wizard is known to be buggy Helmut 2011-11-06 14:14
  - WinNonlin’s BE wizard is known to be buggy yicaoting 2011-11-06 15:38
    - WinNonlin’s BE wizard is known to be buggy Helmut 2011-11-06 16:53
      - WinNonlin’s BE wizard is known to be buggy yicaoting 2011-11-06 17:12
        
        WinNonlin’s power? Helmut 2011-11-06 18:29