Bioequivalence and Bioavailability Forum

Helmut gives good advice re NCA 220 i.e. the PD model.

You may want to also use transform (or multi-transform) to calculate change from baseline.

Also for your endogenous compound you may want to check if the 'baseline' is constant or needs to be modelled with some diurnal or other variation.

Best regards,
Simon.

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