Convergence problem in PROC MIXED [Software]

posted by ElMaestro  – Denmark, 2010-03-23 21:29 (5932 d 14:24 ago) – Posting: # 4966
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Hi dixit,

❝ and for my concern how can I ensure the above one when I analyzed my data by using the earlier mentioned code and found that there is no issue in LogAuclast and LogAucinf but the problem faced on LogCmax only.


I am not sure I t understand what you write here. Can it be rephrased?
But even if I did understand, I might not be able to help you. As usual, d_labes is ahead of everybody else here - please read his post. He pointed out there is something with the model specification and the partial replication of your study.
If you have RRT, RTR, TRR as sequences then there is not point trying to fit a within-T variance estimate. The restricted max likelihood optimises the likelihood of ZGZt+R, and there cannot be a within-T sigma anywhere in it due to your study design. I do not know which syntax forces a within-R but no within-T into the covar matrix.

Did SAS converge with a result when you did the AUC-analysis using the same code lines? If so, then that would be really weird (there's still no within-T in your design). Please post the output, including the within-T variance estimate and the likelihood.


Best regards
EM.

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