Bioequivalence and Bioavailability Forum

Hello Balakotu,

❝ any body tell me i have 2-sequence, 4-treatment and 4-period cross over

❝ study i need SAS Procedure for this study plz help me soon.

❝ Ex:

❝      T1 R1 T2 R2
❝      T2 R2 T1 R1

The SASophylistic evaluation uses the same PROC GLM as for the cassical 2x2 cross over.
Here a code snippet:
Proc GLM data=yourdata;
  class tmt period sequence subject;

  model logAUC=tmt period sequence subject(sequence) /SS3;
  random subject(sequence)/test;

  LSMeans tmt/pdiff CL alpha=0.1;
run; quit;

Don't forget the back-transformation of the 90% CI's.

The code assumes that you have a long dataset i.e. rows with
logAUC subject sequence tmt period as variables.

Eventually you have to adjust the alpha depending on the problem.

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Edit: Welcome back! How was Salzburg? [Helmut]