Bioequivalence and Bioavailability Forum

Dear Helmut, d_labes,

I'm also a little confused about the results that Helmut quoted above. Running that same data in 5.2.1 I get the result of 1 for Tlag in the third group which agrees with the definition in the help file. I don't recall this function being changed for some versions in WNL so is there a typo in your table, or can you send me the workspace for further investigation?

❝ ... Tlag is the time prior to the first measur­able (non-zero) concentration ...

I would agree that probably Tlag lies somewhere between 1.0 and <1.5 but with NCA being model-independent I guess Pharsight decided to go for the prior one but obviously this will be heavily dependent on the sampling schedule so compartmental modelling is probably going to be more useful if you need to define this more 'precisely'.

I concur it would be useful for WNL to 'intrinsically' recognise BLQs but Helmut correctly states that the appropriate process is currently to recode non-numeric values first using (Tools > Status Codes).