Bioequivalence and Bioavailability Forum • First time lag time

First time lag time [Software]

posted by Helmut – Vienna, Austria, 2009-02-02 14:08 (5939 d 06:23 ago) – Posting: # 3172
Views: 10,272

Dear D. Labes!

❝ Meanwhile I came into touch with the lag time (first in my long, long career in BE studies) in a food BE study for one of the "(in)famous" ...prazoles.

Oh dear!

❝ […] I found the following paper […]

❝

❝ What do you think?

Hhm, I didn’t know this paper also. The approach seems reasonably to me.
In PK modeling one would come up with exactly such a value.

❝ What should be done with this parameter? Reporting the values only (with summary statistics) or any statistical analysis of differences between formulations under study? Which statistical method, model?

I remember a paper by H. Blume dealing with gastric resistant diclofenac, where he used t_max-t_lag as a parameter describing the rate (drug dependent) and evaluated t_lag separately (formulation dependent).
The collection of Blume/Mutschler (in German, out of print) contains some examples.

Henning Blume, Ernst Mutschler
Bioäquivalenz
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GOVI-Verlag, Frankfurt am Main/Eschborn, 1989-1996

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Complete thread:

Lag time in WinNonlin - bug or feature? Helmut 2008-05-26 15:26
- Lag time in WinNonlin - bug or feature? d_labes 2008-05-29 16:47
  - WinNonlin <--> Kinetica... / Survey Helmut 2008-05-29 20:03
    - Tlag d_labes 2008-05-30 08:12
    - First time lag time d_labes 2009-02-02 12:48
      - First time lag timeHelmut 2009-02-02 13:08
        
        lag time paper d_labes 2009-02-02 13:42
  - Lag time in WinNonlin - bug or feature? SDavis 2009-02-04 12:49
    - Lag time in WinNonlin - bug or feature? Helmut 2009-02-04 13:05