Bioequivalence and Bioavailability Forum

Dear Helmut,

Thanks for your reply. In my example, 12 hours is not the last sampling timepoint. The following concentrations were above LOQ. In such cases, do we need to mention this timepoint as 12,BLOQ or 12,0 in WinNonlin?

Since 12,BLOQ and 12,0 are treated differently by WinNonlin, which one of these would be the right way of data handling in WinNonlin? Alternately, is it right to totally skip this timepoint entry in WinNonlin?

Thanks & regards,
Dr. Harish L. Rao