Handling Zero Values in WinNonlin [Software]

posted by Dr. Harish L. Rao – India, 2009-01-16 10:35 (5956 d 07:57 ago) – Posting: # 3043
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Dear Group Members,

First of all, wish you all "A VERY HAPPY & PROSPEROUS NEW YEAR 2009".

During WinNonlin data analysis, do we need to include zero values? Eg: If the concentration at 12 hours is below the limit of quantification (BLOQ), do we need to include this timepoint as 12, BLOQ or 12, 0 for WinNonlin data analysis?

If we have measured the concentration prior to dosing & found the concentration to be BLOQ, do we need to include this timepoint as 0, BLOQ or 0, 0?

Does WinNonlin treat 12, BLOQ same as 12, 0?

Thanks & regards,
Dr. Harish L. Rao

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