Bioequivalence and Bioavailability Forum • Simple minded

Simple minded [Software]

posted by d_labes – Berlin, Germany, 2008-12-12 14:28 (5971 d 09:31 ago) – Posting: # 2914
Views: 31,038

Dear Helmut,

❝ ❝ Black magic :confused: or some sort of perpetuum mobile of information?

❝

❝ Neither nor - just the 'power to know'!

❝ For my simple mind it seems to be quite strange to get the variance of a measurement we have performed only once.

I am the last to tout "SAS all over the world" (although I have to deal with the 'power to know' most time of my working day). But here I must defend it.

I guess this is not a problem of SAS. It may be a problem of what we (I) do with it. Fitting an inappropriate? or over-specified? model.

Eventually anybody can fit the underlying model in WINNONLIN or R using REML to see what happens?
I have taken my data to play with from example 4.2 of Patterson/Jones "Bioequivalence and Statistics in Clinical Pharmacology" (C5300.zip with data and SAS code), changed the original sequences to TRR/RTR.

I place a bet that then also a fitted value for s²_WT is obtained :-P

. Maybe it is even correct!?
(I confabulate: total variability of T: estimable; variability of T-R: estimable and sum of intra-subject variabilities + treatment*subject interaction; intra-subject variability of R: estimable; so ......)

BTW: Simple minds are more then 30 years successful :-D

—
Regards,

Detlew

Complete thread:

SAS code of partial replicate design pa1kumar.anna 2008-12-01 09:51
- Etiquette Ohlbe 2008-12-01 10:45
- SAS code for what? d_labes 2008-12-02 09:17
  - partial replicate = 3-period replicate Helmut 2008-12-03 15:42
    - partial replicate = 3-period replicate MGR 2008-12-04 11:19
    - 3-period replicate designs and SAS d_labes 2008-12-04 14:17
      - Extra-reference or partial replicate design d_labes 2008-12-12 10:51
        
        Extra-reference or partial replicate design Helmut 2008-12-12 11:34
        
        Simple mindedd_labes 2008-12-12 13:28
        
        Simple minded Helmut 2008-12-12 14:58
        
        SAS and WinNonlin d_labes 2008-12-12 15:44
        
        SAS and WinNonlin Helmut 2008-12-12 16:33
        
        SAS and WinNonlin BEQool 2024-07-29 09:38
        
        Phoenix RSABE-template Helmut 2024-07-29 13:29
        
        Phoenix RSABE-template BEQool 2024-07-29 19:47
        
        CVw in Phoenix RSABE-template Helmut 2024-07-30 09:15
        
        CVw in Phoenix RSABE-template BEQool 2024-07-30 10:56
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() Helmut 2024-07-30 11:23
        
        CVw in Phoenix RSABE-template and PowerTOST CI2CV() BEQool 2024-07-31 05:49
        
        General ABE? mittyri 2024-07-31 18:25
        
        General ABE? BEQool 2024-08-01 05:45
        
        Switchability and Prescribability in WinNonlin MGR 2008-12-30 10:12
        
        PBE and IBE in WinNonlin Helmut 2008-12-30 16:04
        
        PBE and IBE in WinNonlin MGR 2008-12-31 07:52
        
        Switchability NPavan 2009-01-12 13:10