Log in
Registersteady-state PK parameters = SD PK parameters! [Software]
Dear Helmut,
As per the WinNonlin user manual 5.2, for simulation we need to enter model parameters like k10 (elimination rate constant), k01 (absoprtion rate constant), V_F (volume of distibution). from single dose pk data we can get the value of k10 & V_F. But from where we can get the value of K01? can we calculate it from single dose data using WinNonlin. please guide us.
Also for model 11, following value for model parameter have been given in WinNonlin user manual.
K12=1.5, K21=1
Are they constant value? can we consider these value in our simuation?
regards
chak
As per the WinNonlin user manual 5.2, for simulation we need to enter model parameters like k10 (elimination rate constant), k01 (absoprtion rate constant), V_F (volume of distibution). from single dose pk data we can get the value of k10 & V_F. But from where we can get the value of K01? can we calculate it from single dose data using WinNonlin. please guide us.
Also for model 11, following value for model parameter have been given in WinNonlin user manual.
K12=1.5, K21=1
Are they constant value? can we consider these value in our simuation?
regards
chak
Complete thread:
- prediction of steady-state PK parameters from SD data chak 2008-11-26 14:19
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- steady-state PK parameters = SD PK parameters! Helmut 2008-11-26 15:01
- steady-state PK parameters = SD PK parameters!chak 2008-11-27 17:31
- steady-state PK parameters = SD PK parameters! Helmut 2008-11-27 17:51
- steady-state PK parameters = SD PK parameters! ElMaestro 2008-11-27 19:59
- The power to know d_labes 2008-11-28 08:29
- steady-state PK parameters = SD PK parameters! ElMaestro 2008-11-27 19:59
- steady-state PK parameters = SD PK parameters! Helmut 2008-11-27 17:51
- steady-state PK parameters = SD PK parameters!chak 2008-11-27 17:31
- steady-state PK parameters = SD PK parameters! Helmut 2008-11-26 15:01
Ing. Helmut Schütz