new regression rule for lambda_z in Phoenix: no change in implementation [Software]

posted by SDavis Homepage – UK, 2025-11-11 15:24 (204 d 09:45 ago) – Posting: # 24488
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(edited on 2025-11-11 15:36)

hi, I happen to have a 4.1 user manual on my bookshelf, yes a real book (2003)... and you can see from the attached pages the text is almost the same as in 8.7. My understanding is the only change made was with v6.0 of WinNonlin, first Phoenix version, was not to allow Cmax.

I think the issue maybe the text is slightly ambiguous and people read into it, "and then you stop", however it always went all the way back to Tmax, (and from 6.0+; Tmax+1) before selecting the value with the largest Adj-R-Sq. I think "If the adjusted R2 does not improve, but is within 0.0001 of the largest adjusted R2 value, the regression with the larger number of points is used." infers that but I've asked that we make it clearer in future iterations of the help that all points are assessed.

Long story short, it hasn't changed for 20+years,
Regards, Simon. Manager, Support, Certara.
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