Bioequivalence and Bioavailability Forum • Spreadsheet addiction

Spreadsheet addiction [Software]

posted by Helmut – Vienna, Austria, 2019-07-18 22:04 (2512 d 22:25 ago) – Posting: # 20395
Views: 32,936

Hi Shuanghe,

❝ I was interested in the method so several weeks back I played with R using data from EPAR (none of the articles gives sample size of the BE study so without going to the EPAR for this additional information you can not reproduce/validate their results at all) …

Yep. I wrote a package for this stuff. I think they were using Excel cause (a) everybody has it (b) of its flat learning curve and (c) – most important – Luther Gwaza* gave his “template” to the others.

❝ … and the difference in some comparison is 0.01% due to different rounding method used in Excel and R.

If you want to reproduce Excel’s wacky “commercial rounding”:

cround <- function(x, d) ((trunc(abs(x) * 10^d + 0.5)) / 10^d) * sign(x) x <- c(79.994, 79.995, 125.004, 125.005) comp <- data.frame(x = x, R = round(x, 2), Excel = cround(x, 2)) print(comp, row.names = FALSE) x R Excel 79.994 79.99 79.99 79.995 80.00 80.00 125.004 125.00 125.00 125.005 125.00 125.01

❝ ❝ Semitransparent colors in Excel? I don’t think that’s possible. ;-)

❝

❝ Haha, this is where you err... :-D Actually you can do that in Excel (not that you should). At least I can in my 2013. It's ugly, but semi-transparent it is. :cool:

Well, my version is Excel 2000. BTW, navigate up to my OP and hit ctrlF5 to clear the browser’s cache / reload. Is it possible in Excel to have the color dependent on the value (the lower, the darker)? :smoke:

Gwaza L. Adjusted Indirect Treatment Comparisons of Bioequivalence Studies. PhD Thesis: Utrecht. 2016. free resource.

—
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Helmut Schütz

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Complete thread:

Spreadsheet failures, any recent examples? ElMaestro 2019-07-18 13:43
- Spreadsheet failures, any recent examples? Ohlbe 2019-07-18 14:32
  - Spreadsheet addiction Helmut 2019-07-18 16:12
    - Nasty beast Ohlbe 2019-07-18 17:30
      - Nasty beast Helmut 2019-07-18 20:26
        
        Nasty beast Ohlbe 2019-07-19 11:32
        
        Nasty beast ElMaestro 2019-07-19 12:32
        
        Decidedly off topic Ohlbe 2019-07-19 13:38
        
        OT: R limbo 101 Helmut 2019-07-19 13:00
    - Spreadsheet addiction Shuanghe 2019-07-18 18:59
      - Spreadsheet addictionHelmut 2019-07-18 20:04
        
        OT: Spreadsheet addiction Shuanghe 2019-07-19 12:41
        
        OT: Spreadsheet addiction Helmut 2019-07-19 14:29
        
        OT: Spreadsheet addiction nobody 2019-07-19 15:53
        
        OT: Spreadsheet addiction Helmut 2019-07-19 19:32
  - Spreadsheet etc. failures zizou 2019-07-20 00:18
    - As designed ☺ Helmut 2019-07-20 02:12
      - As designed ☺ ElMaestro 2019-07-20 09:08
        
        To round or not to round… Helmut 2019-07-20 12:53
        
        To round or not to round… ElMaestro 2019-07-20 19:59
        
        floating-point math is always more complex than you think it is mittyri 2019-07-20 22:43
- Spreadsheet failures, any recent examples? Ohlbe 2020-12-10 18:43
  - Floating point arithmetic, again Helmut 2020-12-10 19:12
    - Floating point arithmetic, again ElMaestro 2020-12-10 19:40
      - Floating point arithmetic, again Ohlbe 2020-12-10 20:18
        
        Floating point arithmetic, again ElMaestro 2020-12-10 21:38
        
        Floating point arithmetic, again Ohlbe 2020-12-10 21:46
        
        Floating point arithmetic, again ElMaestro 2020-12-10 22:05
        
        Depressed Ohlbe 2020-12-10 23:35
        
        Depressed ElMaestro 2020-12-11 07:59
    - Floating point arithmetic, again Ohlbe 2020-12-10 20:13
  - From bad to worse Ohlbe 2020-12-10 22:11
    - From bad to worse mittyri 2020-12-11 00:22
    - All is good Helmut 2020-12-11 00:36
      - Float is float PharmCat 2020-12-18 20:53
        
        Float is float! Helmut 2020-12-20 23:27
        
        rational solution in R mittyri 2020-12-21 13:49
        
        related stuff Helmut 2021-01-14 12:53
        
        related stuff SDavis 2021-02-09 12:02
        
        related stuff ElMaestro 2021-02-09 19:55